The common success rate in egg donation procedure varies about 50%. Anyway there are options that may highen the chance of success. The first one is the professionalism of the medical crew. The second to mark is the quality of the donored eggs. If the donors are healthy the success chances improves greatly. And the last point is the usage of the newest technologies. Just a minority facilities offer all the three pros. One of them is AVA-Peter, a Russian reproductive medicine clinics in Saint Petersburg. The next describes treatment they carry out. This allowed them to attain a 70% success rate in oocyte donation in first half of 2009.
Egg donation involves two persons the first one is called an an egg donor and an egg recipient. The egg donor undergoes IVF procedures to produce egg cells. These egg cells are then inseminated in the laboratory by the sperm of the egg recipient's husband partner (or a sperm donor). Theinseminated eggs now become embryos, and a single one or a pair of them are placed back into the womb of the egg recipient to create a pregnancy.
Differences between IVF and IVF with egg donation
The main difference between 'usual IVF' and 'egg donation IVF' is that one more person is necessary to assist to create a pregnancy. This woman is the egg donor, whose eggs are used in case if the potential mother (the egg recipient) cannot make use of her own eggsfor medical reasons to get pregnant. The subsequent is a full explanation of all the process stages.
Synchronising the menstrual cycles
The egg donor and the egg recipient need to be at the start of their menstrual cycles which is needed to begin egg donation treatment procedures. Even if no longer have a normal menstrual cycle, we can start it at the right time.This is done by prescribing contraceptive medicationto both the donor and the recipient according to the decided time-table. The tablets are finished on the same day by both the donor and the recipient, resulting in a menstruation in both ladies.
The egg donor's treatment
Once the egg donor's period starts, she has an ultrasound scan of the uterus and the ovaries to assure the ovaries are idle and the womb lining is thin enough. Your egg donor afterwards takes medication to stimulate her ovaries to form eggs. After 10 days, she uses an additional hormone to make the eggs ready for harvesting. Egg harvesting is performed by aspirating the cells from the follicles via a needle incerted into the ovary via the vagina. Her role is now over.
The egg recipient's treatment
Egg recipients may or may not still have a usual menstrual cycle. Once the period is induced by the pills, you may undertake one or sometimes two extra injections of a 'down-regulating' drug to ensure finest synchronisation with your donor. Frequently, you will after have a inspection to check that the membrane of your uterus is thin and that there are no cysts right before starting the treatment cycle. This involves taking oestrogen tablets, cream and patches to build up your uterine lining again. Five days before the planned day for Embryo Transfer, you start taking progesterone besides oestrogen.
Insemination and embryo transfer
The donor eggs collected are inspermated with the semen of the male partner or a sperm donor. They are grown in our lab for three or (more frequently) five days. For the period of this phase, they continue to divide and grow. At five days old, embryos become| blastocysts. By this phase, our professional embryologists are able to estimate which embryos are of the most promising quality. On the date of embryo transfer, a single or a pair of the best embryos are introduced through the cervical tube into the egg recipient's womb using a threadlike, elastic plastic catheter. This operation is almost always short and provides no pain.
After the embryo incertion, you carry on with using oestrogen and progesterone pills for two weeks and afterwards take a pregnancy test. If the test is positive, you must have a scan to confirm the pregnancy two weeks later. If a 'fetal pole' is noticeable on the scan, this gives clinical confirmation of your pregnancy.
At AVA-Peter, we had a 60% pregnancy rate in 2008. This was the proven clinical pregnancy percentage after replacing 2 fresh embryos at the 5-day-old blastocyst development stage. The total number of children born through egg donation is growing each year as more infertile ladies become acquainted with this form of treatment.